The STEP-1 trial demonstrated mean weight loss of 14.9% with semaglutide over 68 weeks, while the SURMOUNT-1 trial showed tirzepatide achieving 16-22.5% weight reduction over 72 weeks
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This waiting period allows TSH and thyroid hormone levels to reach a new steady state, making it easier to assess tirzepatide's independent effects and adjust antithyroid or replacement medications accurately
The weight loss results from actual GLP-1 injections come from prescription medications delivering precise doses directly into your bloodstream
When hormone byproducts are not properly detoxified, they can accumulate and disrupt hormonal balance
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