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Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects

drowsiness & amnesia Toxic doses can cause excitement, agitation, hallucinations & coma (more likely than with atropine)

This pattern suggests GHK-Cu provided temporary stimulation rather than inducing self-sustaining structural changes, requiring continuous or cyclical application for maintaining optimal results

Nyalwidhe, J

Yet some adverse effects are possible at lower doses, although theyre temporary and not life-threatening

[1] Why Glutathione Levels Decline With Aging Like many biological molecules, glutathione levels decrease as people get older