Severe obesity, a susceptibility factor for developing inflammatory bowel disease: results of a population-based study
and Paulson, D.J
For complete picture, it's worth mentioning another popular product Ozempic with active ingredient semaglutide
Together, they attack appetite from two different angles
The honest answer is that the strongest evidence supports titrating to established therapeutic doses, while microdosing specifically has far less direct trial data behind it
Lancet 402:472483 Fricker G, Fahr A, Beglinger C, Kissel T, Reiter G, Drewe J (1996) Permeation enhancement of octreotide by specific bile salts in rats and human subjects: in vitro, in vivo correlations