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Intestine-specific gene transfer experiments of pancreatic and duodenal homeobox-1 ( Pdx1 ) siRNA in 810-week-old mice reveal that posteriori suppression of Pdx1 decreases K-cell number, intestinal GIP protein and mRNA expression, and GIP secretion in response to an oral glucose tolerance test (OGTT) (Ikeguchi et al., 2018)

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The only complication was mild transaminitis, attributed in part to acetaminophen use for back pain and headache, which resolved after discontinuation

10.1016/j.brainres.2009.02.075 64 LindblomJ.OpmaneB.MutulisF.MutuleI.PetrovskaR.KlusaV.et al