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It increases proliferation and the levels of collagen and secreted pro-matrix metalloproteinase-2 (MMP-2) in isolated human fibroblasts when used at a concentration of 1 nM

Preclinical investigations indicate that the peptide may attenuate behavioral and functional disturbances in rodent models of neurodegeneration induced by neurotoxic agents such as MPTP and reserpine

For investigational peptides, BPC-157 has the most direct preclinical evidence specifically for bone defect healing, with the Sebecic rabbit study showing complete bony continuity in treated animals while controls remained unhealed

Relative mRNA expression was determined using the GoTaq 1-step real-time quantitative PCR (RT-qPCR) system (TAKARA) and qPCR using SYBR premix Ex Taq kit (TAKARA), and RT-qPCR was performed on an ABI Prism 7500 Fast Real-Time PCR System (Applied Biosystems, CA, USA)

doi:10.1016/j.ctim.2018.09.023 Bangratz M, Ait Abdellah S, Berlin A, et al

It also acts as a localised 5-alpha reductase inhibitor, reducing DHT at the scalp level