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Other licensed pharmacological options : For patients unsuitable for or unable to tolerate Wegovy, alternatives include: Orlistat (lipase inhibitor that reduces fat absorption) Liraglutide 3mg (another GLP-1 receptor agonist, recommended by NICE TA664 for specific patient groups, though local NHS availability may vary) Consideration of bariatric surgery referral for eligible patients with severe obesity Medically supervised diets : If rapid weight loss is clinically indicated (e.g., pre-bariatric surgery), options include: Very low-calorie diets (800 kcal/day) under specialist supervision for up to 12 weeks Low-calorie diets (8001200 kcal/day) with appropriate nutritional support These differ fundamentally from HCG protocols as they provide adequate protein, vitamins, and minerals and are used within NHS-approved frameworks
Retatrutide is an investigational triple-agonist (GLP-1, GIP, and glucagon) with a half-life of roughly 6 days (Coskun et al., Cell Metabolism, 2022)
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Can they be combined
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