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Although not FDA-approved, enclomiphene has been evaluated in several studies for men with secondary hypogonadism

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Grespan E, Giorgino T, Natali A, Ferrannini E, Mari A

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Significant prior efforts across the pharmaceutical industry have generally failed to identify potent and efficacious smallmolecule agonists of the GLP-1R, although a recent report has revealed the identification of a potent, nonpeptidic orally active agonist series (exemplified by LY3502970), which is structurally distinct from danuglipron

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