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Melanin pigmentation is a common feature of the oral mucosa
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For instance, dosages of 0.3 mg were shown in studies conducted in the mid-1990s by researchers at the Massachusetts Institute of Technology to promote sleep onset without disrupting sleep architecture
GLP-1 receptor agonists should not be used in combination with DPP-4 inhibitors (such as sitagliptin), as both act on the incretin system
While this evidence is promising, researchers emphasize the importance of larger, more definitive studies to confirm these effects and establish optimal dosing and treatment durations