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One American-based study estimated the additional annual cost associated with obesity in men was US $1152 and in women was US $3613, which given the high prevalence of obesity in the US led to an estimated spending of about $190 billion per year (21% of total healthcare spending) [4]
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In a phase I clinical trial, bivamelagon was given to obese and overweight participants in SAD and MAD arms of the trial (NCT06040372) (101, 102)
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Despite having a similar active component, Eli Lilly and Company markets them independently for their distinct indications: weight reduction (Zepbound) and type 2 diabetes control (Mounjaro)
10.1021/bi00518a039 Biochemistry 62 FerrettiM
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