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Semaglutide produces approximately 15% weight loss, tirzepatide achieves around 21%, and Retatrutide delivers over 24% in clinical trials
Neither method is automatically best for every patient
The enzyme glutamine phosphoribosylpyrophate amidotransferase (GPAT) catalyzes this reaction and is the committed step in purine synthesis (figure 7.7)
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Since most people who take GLP-1s eat less, this may affect diet quality and potentially lead to nutritional deficiencies
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