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Skillbck et al., 2017) indicate the vulnerability of the NVU in Alzheimers disease, the most common neurodegenerative disease (Muoio et al., 2014), and both protective and trophic functions of the neural barrier seem to be impaired (Zenaro et al., 2017)
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Moreover, traditional drug delivery systems (DDSs)primarily oral tablets and intravenous injectionsfail to address localized MSU crystal deposition or provide sustained drug release, leading to recurrent flares and chronic joint damage (Mohamad et al., 2025
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