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IL-18 acts in synergy with IL-12 to stimulate T cells production of IFN-, which in turn stimulates synovial macrophages to produce TNF- and IL-1, leading to joint inflammation and cartilage destruction (79)

Finally, this effect is apparently not species specific, and it was seen in the bigger animals as well

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FDA Is Expected to Lift Restriction on Peptides, Heeding RFK Jr.s Wishes. March 2026

Published dosing context mainly involves topical clinical-study use, diabetic-ulcer wound studies, and newer registered topical wound-healing trials, not an FDA-approved injectable label [3], 7