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Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial

Interestingly, the study also noted striking sex-based differences

Therefore, it is known that, in some cases, where the liver is unable to perform effectively (whether it be from clinical disease, medications, alcohol abuse, protein digestion issues such as leaky gut, lack of stomach acid (PPIs), NFLS or gluten intolerance), the build-up of toxins and the use of amino acids for detoxification could suffer, as the availability of amino acids for its functionality is challenged

Antioxidant balance plays a role in overall skin appearance