Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15
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doi: 10.3389/fped.2018.00412 5 JasonLAKatzBZSunnquistMTorresCCotlerJBhatiaS