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In contrast, the GH-antagonist pegvisomant has been shown to improve glucose metabolism whether applied as monotherapy or added to treatment with somatostatin analogs (36)

That gives it a clean theoretical connection to testosterone biology: GnRH can increase pituitary gonadotropin signaling, and LH is the key downstream signal for Leydig-cell testosterone synthesis

Applying those same ingredients to the skin introduces an absorption barrier that has not been validated for this purpose

p = 0.013, as shown in Table 2)