Skin purging, similar to what occurs with retinoids, happens occasionally
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In contrast, semaglutide, alongside similar weight loss drugs like Zepbound (tirzepatide), have gone through extensive reviews and are FDA-approved
Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content