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Although no formal drug-interaction studies exist in this context, caution is warranted

Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

Shots work quickly because they skip digestion, and a plan built around bloodwork helps you get the most from each one

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The fact that you have to go to your doctor to administer the injection, is another reason many people will choose supplements, rather than the injection form