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3 Primary end points at Week 72 1 Resolution of steatohepatitis and no worsening of liver fibrosis Resolution of steatohepatitis is defined as a score of 0-1 for lobular inflammation, 0 for ballooning, and any value for steatosis (according to MASH CRN) At least one stage improvement in liver fibrosis and no worsening of steatohepatitis No worsening of steatohepatitis is defined as no increase from baseline in score for ballooning, lobular inflammation, or steatosis Select confirmatory secondary end point at Week 72 1,3 Resolution of steatohepatitis and no worsening of liver fibrosis Select supportive secondary end points at Week 72 4 Change from baseline in average ALT Change from baseline in average AST ALT, alanine aminotransferase

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