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In obese anovulatory women, GLP-1-associated weight loss restores menstrual cycling and increases ovulation

without those steps most peptides would be cleaved and rendered inactive before reaching the bloodstream

Thus, the affinity to IRAP was improved after an enlargement of the P1 as exemplified by 44 (DG026) exhibiting an IC50 of 32 nM while the affinity to ERAP1 dropped 100-fold

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