Additionally, individuals with autoimmune or gastrointestinal disorders, such as pernicious anemia, celiac, or Crohns disease, are more likely to be at risk of deficiency
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The RBC partitioning rate is calculated by measuring the ratio between the concentrations of the drug in the RBC compartment and those in the plasma or buffer
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It modulates the nitric oxide (NO) system in a bidirectional manner, meaning it can counteract both NO-excess states (like those caused by L-arginine or NO donors) and NO-deficiency states (such as those induced by L-NAME)