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The coefficient of variation for orforglipron plasma exposure (AUC and Cmax) across Phase 1 studies was moderate and consistent with typical oral small-molecule drugs, whereas oral semaglutide shows substantially higher variability due to the sensitivity of SNAC-mediated gastric absorption to physiological factors including gastric pH, motility, and volume
Available at: Lamija Ferhatbegovi, Mri, D
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Author contributions AA: Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing original draft
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