Sulfonylurea discontinuation: Often possible and reduces hypoglycemia risk
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But the addition of GIP receptor activation in tirzepatide creates what researchers describe as a synergistic effect
Tirzepatide# Tirzepatide is a 39-amino acid dual GIP/GLP-1 receptor agonist with approximately 5-fold potency at GIPR relative to native GIP and 0.2-fold at GLP-1R relative to native GLP-1
With a mean weight loss of 14.8%, the progress decimates the 2.4% weight loss in the placebo group (Garvey et al., January 2023)
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