Key Takeaways Tirzepatide (Zepbound) produces greater average weight loss than semaglutide (Wegovy) across both clinical trials and the first direct head-to-head comparison, 20.9% versus 14.9% in separate Phase 3 trials, and 20.2% versus 13.7% in the SURMOUNT-5 trial published in the New England Journal of Medicine
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Tirzepatide Lys 16 may slightly decrease GLP-1 activity, but it enhances GIP activity
[21] However, it is important to note that these findings are preliminary, many are based on animal or in vitro studies, and there is no official link established between allulose consumption and clinically significant enhancement of GLP-1 activity in humans