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however, this literature is heterogeneous and, in some cases, characterised by retrospective studies, inconsistent diagnostic criteria, and other methodological shortcomings
APE1 also negatively regulates nuclear factor erythroid-related factor 2 (NRF2), a prominent antioxidant that is protective against oxidative damage triggered by injury and inflammation (Fishel et al., 2015)
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doi:10.1016/j.tibs.2008.11.002
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