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The mixed Rex domain NAPstar4.3 for example has no detectable binding affinity for NADH and has a K dNADPH 43 M and a K r(NADPH/NADP+) 0.28, which is approximately one order of magnitude lower than that of other NAPstar sensors (Fig

Signs of inadequate hydration include dark urine, headaches, dizziness when standing, and fatigue

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Acknowledgments We would like to thank TW for providing the experimental platform (Research Center for High Altitude Medicine, Qinghai University) and Editage (www.editage.cn) for English language editing

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