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These findings indicate that just as HIF-1 generally affects glucose metabolism in hypoxia, HIF-2 also plays a distinct role in glutamine metabolism to promote metabolic adaptation in hypoxia (Fig

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Alongside its effects on GLP-1, it also mimics the actions of another hormone called GIP (gastric inhibitory polypeptide) that reduces blood sugar levels

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The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo. 2005 Anderson, J., et al