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Same here: there is meaningful, sometimes dramatic change, but it is contingent on continued use

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The IV (intravenous) method of administration allows much higher doses of glutathione to enter the cells than would otherwise be possible by dietary modification or oral supplements

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Peripheral neuropathy, subacute combined degeneration of the spinal cord, or cognitive impairment indicate more advanced deficiency and generally require intensive treatment over extended periods

doi: 10.1172/JCI196346