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Women themselves are offering plenty of theories, many of which echo what clinicians suspect: Weight loss and oestrogen release : Fat tissue stores oestrogen

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The SURMOUNT trials in patients without diabetes showed even greater weight loss, with the 15 mg dose producing an average loss of 20.9 percent of body weight at 72 weeks compared to 14.9 percent for semaglutide in similar populations

an effect that may be due to compensatory mechanisms in response to the marked reduction of body weight after chronic treatment with GLP1/E