tirzepatide explained Tirzepatide: How Does It Work for Weight Loss? │ Pharmacology What Is Tirzepatide? How It

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Phase II clinical trial results demonstrated: Body weight reduction of up to 2% at 48 weeks ( vs 2.1% placebo ) 83% of participants achieved 15% body weight loss at highest dose HbA1c reduction of up to 02% in Type 2 Diabetes participants ( vs 0% placebo ) Normalization of liver fat in 86% of participants with hepatic steatosis Reduction in systolic blood pressure averaging 6-8 mmHg Phase II findings are preliminary

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In the SURMOUNT-1 phase-3 trial, tirzepatide produced dose-dependent weight loss reaching about ~21% of total body weight at the 15 mg dose, substantially more than placebo, with gastrointestinal symptoms the most common adverse events [6] [7]

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