The liposomal form protects glutathione bonds from the degradation that can occur in digestion
This works, but it's painfully slow, and adherence becomes the limiting factor
This form typically progresses slowly over years
However, because they initially absorb through oral membranes, bypassing the stomach to go straight to the bloodstream, they shouldnt need as high of a dose.6 Research indicates a certain amount of difficulty absorbing peptides through regular digestion, so sublingual absorption could prove superior.7 The only problem is that sublingual delivery mechanisms for semaglutide haven't been tested to establish an effective dose outside of the compounding pharmacy industrys internal publications, which are more marketing materials than clinical research
Emerging evidence further indicates that NNMT may influence epigenetic regulation through its effects on cellular methyl donor availability
Nature 570 , 246251 (2019)