Although stroke was not a primary outcome in RCT that assessed the effect of GPL1RA in high-risk patients, subgroup analyses of several CVOTs suggest that these medications may reduce the risk of cerebrovascular injury
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however, during diffuse sympathetic activity (and also during cold exposure), stimulation of glucagon secretion is to be expected and, because of this, glucagon may be considered a stress hormone [55]
In the below sections, we will explore the details: exact formulations, trial readouts, degree of weight loss observed in pivotal and ongoing trials
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