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Competing interests The authors declare that they have no competing interests

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For the assembly of DDB1-DET1-DDA1-COP1 complex, His-tagged DDB1, TSF-tagged human DET1, GST-tagged COP1 and untagged DDA1 were co-transfected into Expi293F cells as previously described

The cardiovascular system presents unique regenerative challenges due to the limited proliferative capacity of cardiomyocytes and the complex vascular networks required for tissue perfusion, yet the GLOW Blend's components demonstrate remarkable potential in cardiac research models through complementary mechanisms addressing cardiomyocyte survival, angiogenesis, and tissue remodeling

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