General detoxification and stress responses are mediated by oxidized lipids through TGA transcription factors in Arabidopsis
Tier 3 (same-day evaluation): Right-upper-quadrant pain radiating to the shoulder, severe abdominal pain, jaundice, signs of dehydration (orthostatic dizziness, dark urine, heart rate above 100 at rest), or inability to tolerate any oral fluids for 12 hours
Clinical guidance suggests starting with manufacturer recommendations as outlined in FDA labeling, then adjusting based on individual response
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doi:10.1098/rsfs.2019.0057
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