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The toxicity of intramuscularly administered rotigotine behenate-loaded PLGA microspheres (rotigotine loading of 22.527%) was evaluated over a 20-week period in Sprague Dawley (107 males and 107 females) rats which received 5 doses of rotigotine behenate-loaded PLGA every 28 days at different doses 60, 180, and 540 mg/kg (calculated as rotigotine) 137
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This dual-action approach enhances appetite suppression, improves insulin sensitivity, and further slows gastric emptying
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Local hypersensitivity reactions may manifest as pruritic rashes, urticaria-like lesions, or persistent erythema extending beyond the immediate injection site
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