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The Vmax of enzymes in the pathway is vastly different in magnitude which implies that some enzymes are more active than others
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Monitoring for Dysesthesia in Clinical Practice Baseline Assessment (Before Starting Retatrutide) Neurological Screening: Check for pre-existing neuropathy (diabetes, B12 deficiency) Document baseline sensation in hands/feet Review medications that affect nerves Assess risk factors (alcohol use, vitamin deficiencies) Patient Education: About 1 in 5 to 1 in 8 patients on the highest dose develop abnormal sensations like tingling or numbness (20.9% in TRIUMPH-4, 12.5% in TRIUMPH-1)
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