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Preclinical studies have shown that PD-1/PD-L1 blockade can mobilize monocyte-derived macrophages, enabling their infiltration into the brain to reduce pathology and combat cognitive decline in 5XFAD AD mice [350, 351]

And it's the same thing with health advice

Your body simply doesnt need that much vitamin C

This protective effect was found across subgroups of patients with and without diabetes and across different subtypes of noninfectious uveitis, according to a study published in JAMA Ophthalmology
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Is essential for the synthesis of collagen
