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Abdulmughni LA, Al-Sanabani JA, Gilan WM, Issa MA, Jowah HM

Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal and human studies

General recommended measures are raising the head of the bed to 30 degrees and preventing fever, hypoglycemia, or hyperglycemia

Oncogenic Potential (Cancer Risk) Both peptides encourage angiogenesis (blood vessel growth) and cell proliferation

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21: 206573 Data on file, Searle (Pharmacia), 2000 Roujeau J, Kelly J, Naldi L, et al