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This occurs through several potential mechanisms: IGF-1 stimulates collagen synthesis and cartilage matrix expansion Growth signalling in synovial tissue may increase fluid production Systemic effects on sodium and water handling This side effect is typically mild and reversible

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In addition, both male and female genital ridges lacked PGCs at E12.5 (Fig

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During this stage, mild symptoms might begin to appear, such as fatigue, dizziness, or poor concentration