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Why Aetna might deny Zepbound coverage for weight loss Aetna might deny Zepbound coverage for weight loss for a few reasons: No prior authorization
(2023, February 23)
In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
Unlike semaglutide (a large peptide requiring specialized absorption technology), orforglipron is a small molecule that absorbs more reliably through the GI tract, can be taken with food, and is cheaper to manufacture
