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2012 Modulates 4,000+ genes including DNA repair, antioxidant defense, and anti-inflammatory pathways toward healthier expression patterns
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3.2 Metformin and heart failure Heart failure (HF) is a clinical syndrome characterized by symptoms and/or signs resulting from structural or functional cardiac abnormalities, confirmed by elevated natriuretic peptide levels or objective evidence of pulmonary or systemic congestion ( 3.2.1 Preclinical evidence Experimental studies have shown that metformin exerts cardioprotective effects through multiple complementary mechanisms
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