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Avoid Over-Treating the Skin Overuse of acne treatments or harsh scrubbing can cause irritation, redness, and further breakouts

We used the proportion of patients covered as it is less affected by the length of the grace period compared with time-to-event analyses, and takes not only discontinuation but also reinitiation of treatment into account [31]

The titration schedule starts at 2 mg per week for 4 weeks, escalates to 4 mg for weeks 5 through 8, then to 8 mg for weeks 9 through 12, and reaches the 12 mg maintenance dose at week 13 (Jastreboff et al., NEJM 2023)

While this peptide is a potent agonist for cAMP production, it is a biased agonist, with a preference for G protein-mediated signalling relative to -arrestin recruitment when compared to GLP-1 and exendin-4 26

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