The CALR gene encodes for calreticulin, which is a calcium-binding protein located in the endoplasmic reticulum and nucleus 26
Perluigi M, Poon HF, Maragos W, Pierce WM, Klein JB, Calabrese V, et al
ROSE-010 delayed gastric emptying in some patients but also increased colonic transit at larger doses, perhaps improving constipation resolution in IBS-C
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Eli Lilly has seven Phase 3 trials expected to report results in 2026, with potential FDA approval projected for 2027
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