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If Grade 2 nausea persists despite pausing escalation, or if vomiting occurs, the dose should be reduced to the last well tolerated dose rather than discontinued

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However, electrophysiological studies revealed that GLP-1 or exendin-4 does not change the spontaneous firing activity as well as the synaptic transmission suggesting lack of functional GLP-1R in PPG neurons (Hisadome et al., 2010)

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The results were a bit better (or worse, depending how you look at it) than he expected

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