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Because there is not enough high-quality human evidence to support routine clinical use and they are not currently approved for use in Humans by Health Canada or the FDA

Biochem J 2002

and TB-500 grabs onto a cell's internal scaffolding protein (actin) to help cells move quickly to where they're needed

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Glutathione: Glutathione is a powerful antioxidant that is thought to help brighten the skin and reduce the production of melanin, the pigment that gives the skin its color