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As a result, payer approval-related demand losses for diabetes GLP-1s total 25%, significantly lower than the 48% seen in obesity

Even at 200 times the dose needed for growth hormone release, it didn't raise cortisol or prolactin

These direct effects are further supported by human studies demonstrating the wide expression of GLP-1 receptors in the proximal tubules, juxtaglomerular cells, hilar and intralobular arteries, and preglomerular vascular smooth muscle cells [49]

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