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Separately, 10 mg of PTX (Sigma-Aldrich, USA) was dissolved in 1 mL of deionized water, and 10 mg of TPP (Sigma-Aldrich, USA) was dissolved in 10 mL of deionized water to prepare a 0.1% (w/v) TPP solution

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A review of 11 studies found that lactitol supplements helped improve constipation symptoms and were well tolerated (20)