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Severe Gastrointestinal Disease Those with severe gastrointestinal diseases or disorders may need to exercise caution or explore alternative treatment options, as semaglutide could affect the digestive system
This aspect was important considering that GLP-1 has key interactions with GLP-1R at both ends of the peptide 27,30
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Choose retatrutide alone when you want the simplest protocol with strong single-agent efficacy
In Phase 3 SURMOUNT trials, Retatrutide achieved unprecedented 24.2% mean weight loss at the 12mg dose over 48 weeks, with 91% of participants achieving 15% body weight reduction
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