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In summary, we have demonstrated that a single amino acid replacement of leucine-973 in the juxtamembrane region of IR to phenylalanine, which is the equivalent residue in the IGF1R, is sufficient to lead to a decrease of IRS-1/PI3K/Akt/mTORC1 signaling and an increase of Shc/Gab1/MAPK cell cycle signaling
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A one-sided heuristic p-value and adjusted p-value (Benjamini-Hochberg) is calculated to rank the most likely metabolites per m/z value
Bacteriostatic Water is the gold standard for reconstituting IGF-1 LR3, ensuring stability and sterility for multi-use vials
doi: 10.1186/1755-8166-5-30 128 MullerN
Ital J Gastroenterol
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