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Rapid weight loss and nutritional stress are well-known triggers for a condition called telogen effluvium , a temporary shedding phase where more hairs than usual shift into the resting (telogen) stage and fall out Recent data suggest that people losing more than about 1520% of their body weight in a relatively short time are especially likely to report shedding, regardless of whether they used GLP-1s or more traditional diet methods In other words, for many people the issue is less Does Ozempic directly cause hair loss? and more Is the speed and style of weight loss putting my hair under stress? What the latest research says about GLP-1 Ozempic hair loss Emerging research has started to look specifically at GLP-1 medications and hair shedding: A large real-world cohort study found a higher incidence of non-scarring hair loss (including telogen effluvium) in people using GLP-1 receptor agonists compared with some other diabetes therapies, though it couldnt prove direct causation

Jun 2021;139:109722

Hamilton JJ, Hahn P

When oxidative stress increases, GSH is consumed to neutralize ROS and is converted into GSSG (oxidized form)

PMID 18397884