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Inhibition of HIF-1 activity has a significant inhibitory effect on primary tumor proliferation and metastasis to lymph nodes and lungs in mice by orthotopic transplantation of TNBC (251, 252)
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The regulatory status of these compounds may evolve, requiring ongoing attention to legal requirements
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The risk is highest in the first six months of treatment and includes about twice the likelihood of needing gallbladder removal surgery
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